Properties are selected based on real traveler reviews and popularity among guests who’ve booked a night in Mytilene on Hotels.com. These Mytilene hotels consistently deliver on quality, location and traveler experience. Last updated on .
Hotels in Mytilene
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Where to stay in Mytilene?




1. Hotel Lesvion
Hotel Lesvion



2. Akti Vigla Premium
Akti Vigla Premium



3. Loriet Hotel
Loriet Hotel



4. Theofilos Paradise Boutique Hotel
Theofilos Paradise Boutique Hotel



5. Mythical Coast Wellness Retreat
Mythical Coast Wellness Retreat



6. Elysion Hotel
Elysion Hotel



7. Heliotrope Hotels
Heliotrope Hotels



8. Lasia Hotel
Lasia Hotel



14. Panselinos Hotel
Panselinos HotelGet last-minute hotel deals in Mytilene and save more
Check out pet-friendly hotels in Mytilene
Go beyond your typical stay in Mytilene
Top landmarks in Mytilene
Mytilini Castle
Thermes Gera Hot Springs
Thermi Beach
Church of Taxiarches
Roman Aqueduct at Moria
Archaeological Site of Thermi
St Hermogenes Charamida Lesvos
Theophilos Museum
Learn more about Mytilene
Notable for its seaside, Mytilene features attractions such as Port of Mytilene and Mytilini Castle.
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Check out reviews of Mytilene hotels guests love
Ampoulos Rooms & Apartments
"Very friendly family hotel"
Lasia Hotel
"Lovely people, my only complaint is that the room was a bit outdated and the breakfast had few selections though the food quality was good. The staff could not have been more friendly or helpful and it is an excellent choice for location."
Blue Sea
"Long delay to check in however the hotel delivers a very clean environment, comfortable rooms and views and located in ideal location."
Theofilos Paradise Boutique Hotel
"Staff was nice. Large breakfast spread. Location is great."
Loriet Hotel
"Our vacation at the Loriet Hotel in Mithilini was amazing. Everything was perfect. We really had very good time in there. Thanks for the hospitality and the hygiene conditions. Having new plans for coming back again."
Paradisos studios
"This hotel is owner operated. Owner directly helped me to check in. Room was clean and spacious. Phenomenal value for the money. It is the 3rd time we have stayed at Paradisos. "
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Find out more about Mytilene
Whispers of History and Nature: Discover the Allure of Mytilene
Nestled on the enchanting island of Lesvos, Mytilene is a captivating blend of history, culture, and Greek hospitality. This vibrant port town boasts stunning views from the imposing Mytilene Castle, where ancient ruins whisper tales of the past. Stroll through charming streets lined with museums and monuments, and savor delicious local cuisine at waterfront tavernas. With welcoming accommodations and a serene atmosphere, Mytilene invites travelers to explore its rich heritage, picturesque landscapes, and the warm embrace of the North Aegean. Whether you're a history buff or a beach lover, Mytilene offers an unforgettable experience off the beaten path.
Discover great hotels near Mytilene
Mytilene offers a range of accommodations, from cozy boutique hotels to larger establishments with modern amenities. Room rates vary, catering to different budgets, and guest reviews often highlight hospitality and comfort. Enjoy local charm while exploring hotel deals to enhance your stay in this beautiful part of Greece. Here are some of the best hotels near Mytilene that our travelers love:
- Ariadnes Holiday AccommodationOpens in a new window: This inviting 3.0-star guesthouse offers a memorable beach vacation experience, boasting a remarkable guest rating of 9.4 out of 10. With direct access to the beach, travelers can indulge in sun-soaked days by the sea. The property provides a comfortable and relaxed atmosphere, making it perfect for those seeking a serene getaway. The emphasis on comfort and convenience ensures a delightful stay, and the positive sentiments highlight the enjoyable beach environment that enhances the overall travel experience.
- Ariadnes Holiday Accommodation IIOpens in a new window: Ariadnes Holiday Accommodation II is a charming 3.0-star guesthouse that excels in offering a luxurious beach vacation experience, with an impressive guest rating of 9.6 out of 10. Known for its direct access to the pristine beach, this property creates an idyllic atmosphere for leisure travelers. The well-appointed accommodations and inviting ambiance make it a favorite among those who appreciate comfort and relaxation. The consistently positive reviews reflect a strong appreciation for the serene environment and high-quality amenities that contribute to a memorable stay.
- Aeolis Apartments & StudiosOpens in a new window: Aeolis Apartments & Studios is a unique 3.0-star guesthouse that caters to travelers in search of a rejuvenating hot spring and spa-themed vacation experience, receiving a notable guest rating of 8.0 out of 10. With natural hot springs nearby and a full-service spa, guests can indulge in a variety of treatments designed for relaxation and wellness. The property's inviting amenities create a tranquil retreat, making it a top choice for those focused on self-care and rejuvenation. The positive sentiments reflect appreciation for the soothing environment and the luxurious spa offerings that elevate the overall experience.
Where to stay in Mytilene
Some great areas to stay in Mytilene, Lesvos, North Aegean Islands, Greece, are Lesvos, Varia, and Ano Chalikas. Lesvos offers rich museums and historical ruins, Varia is known for its beautiful sea views and island vibes, while Ano Chalikas boasts charming island landscapes. For first-time visitors, Lesvos is ideal due to its cultural attractions and accessibility to Mytilini.
- LesvosOpens in a new window: Lesvos is a captivating destination known for its rich history and cultural experiences. With a variety of museums showcasing ancient artifacts and local art, it’s a great place for those who appreciate the arts and history. Don’t miss the stunning archaeological ruins scattered throughout the island, including ancient theaters and temples. The island's diverse landscapes, from picturesque beaches to lush hillsides, offer a relaxing backdrop for leisurely exploration. Plus, you can indulge in the local cuisine, famous for its olive oil and ouzo, making Lesvos a delightful spot for food lovers.
- VariaOpens in a new window: Varia is a charming seaside area that offers a serene environment, perfect for travelers looking to unwind by the water. The beautiful coastline and inviting beaches make it an ideal spot for sunbathing and swimming. Visitors can explore local shops that feature handmade crafts and souvenirs, providing a taste of the island's unique culture. Varia also boasts a welcoming atmosphere, with friendly locals who are always eager to share stories and recommend hidden gems around the area.
- Ano ChalikasOpens in a new window: Ano Chalikas presents a quieter escape with stunning island views and a laid-back vibe. This area is perfect for those looking to experience traditional Greek village life. Enjoy leisurely walks through its scenic streets, where you can admire local architecture and take in the beauty of the surrounding countryside. While it may not be bustling with attractions, the tranquility of Ano Chalikas offers a refreshing break from the more tourist-heavy spots, making it a great place to relax and appreciate the natural beauty of Lesvos.
Things to do in Mytilene
Mytilene enchants visitors with its stunning coastal scenery, lush hills, and rich heritage. Explore charming streets lined with historical monuments, relax on picturesque beaches, or hike through serene parks and forests. With welcoming hotels nearby, it's a delightful spot for both relaxation and exploration.
- Teriade MuseumOpens in a new window – Discover a treasure trove of modern art at Teriade Museum, where you can admire works from renowned artists. This intimate museum offers a glimpse into the creative spirit of the 20th century, making it a must-visit for art enthusiasts and curious travelers alike.
- Molyvos CastleOpens in a new window – Step back in time as you explore the impressive Molyvos Castle, perched on a hill overlooking the charming village. Wander through its ancient walls and enjoy breathtaking views of the sea and surrounding landscape. Don’t forget your camera; the scenery is picture-perfect!
- Eftalou Hot SpringsOpens in a new window – Unwind in the soothing waters of Eftalou Hot Springs, where natural thermal springs offer a relaxing escape. The healing properties of the mineral-rich waters make for a rejuvenating experience, perfect after a day of exploring.
- MólyvosOpens in a new window – Spend a leisurely day at Mólyvos beach, where you can bask in the sun or take a dip in the clear Aegean waters. The beach’s serene atmosphere and stunning surroundings create an ideal backdrop for relaxation and enjoyment.
- Monastery of Saint RaphaelOpens in a new window – Visit the serene Monastery of Saint Raphael, a significant religious site filled with rich history. Enjoy the tranquil ambiance as you explore the beautifully adorned interiors and learn about the stories that shaped this sacred place.
5 tips for savvy savings when booking a hotel in Mytilene
- Book for the cheapest times: The most budget-friendly time to visit Mytilene is during February, March, and November, when hotel prices are typically lower. For an enriching experience that allows you to fully appreciate the city's historical landmarks and cultural attractions, it's recommended to stay for at least 4 to 5 days. During your visit, you can explore impressive sites such as museums, the castle, ancient ruins, and beautiful churches, as well as enjoy the picturesque marina and port. This timeframe offers great value for money while immersing yourself in the rich history and architecture of Mytilene.
- Instant discounts. Rewards for later: Save up to 20% instantly on hundreds of thousands of properties with Member Discounts. Then earn rewards on eligible stays to use on future trips. Book once, win twice, get instant discounts and rewards. Join for freeOpens in a new window.
- Score last-minute deals on Hotels.com: Last-minute travel doesn't mean last-minute stress. Hotels.com's Last-Minute DealsOpens in a new window offer discounted rates close to your travel date, so the later you leave it, the more you could save. Turn on push notifications and you'll be the first to know when dealsOpens in a new window drop for Mytilene.
- Book with confidence, not guesswork: Prices in Mytilene shift with the season, local events, and how far out you book — but you don't have to guess. Hotels.com shows you the full price upfront with no surprises at checkout, and our price tracker tells you whether your dates are above or below average. So if you're flexible, you can shift your trip by a day or two to avoid peak season prices, compare pricesOpens in a new window and know you're getting a good deal before you commit.
- Think beyond the city center: Central hotels may come with a central price tag. A well-connected neighborhood a little further out may cut your hotel bill and can often give you a more local experience. Use Hotels.com's map view to find the sweet spot between location and value, and filter by price to see what's available across Mytilene.
Best time to go to Mytilene
Mytilene experiences its lowest average temperature in January, at 49.3°F (9.6°C), while August is the hottest month, with an average temperature of 80.1°F (26.7°C). January is typically the wettest month. If you’re looking to soak up the lively atmosphere in Mytilene, July to September are the peak months to visit, bustling with fellow travelers. During this peak period, the weather is sunny, with no rainfall. However, if you prefer a more relaxed experience, January, February, and December are perfect for a quieter getaway, marked by light rainfall and mostly sunny conditions.
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